Job Description

A clinical-stage biotechnology company headquartered in the Bay Area is seeking a highly skilled, proactive High-Throughput Synthetic Chemist to join its Discovery Synthesis team. This role will support a small-molecule research pipeline through the design and rapid delivery of high-quality compounds (milligram to multi-gram scale). We are particularly interested in chemists who have applied modern synthetic technologies to solve complex problems, including areas such as photocatalysis, electrochemistry, or transition metal catalysis, ideally within high-throughput or parallel experimentation environments. This modern catalysis would be in the specific areas of radical cross couplings (transition metal, photochemical, or electrochemical catalysis). Additional key experience would be with "sp2/sp3" or "sp3/sp3" cross couplings.

Location: South San Francisco, CA (Onsite)

Key Responsibilities
Design and synthesize small-molecule analogs.
Develop and execute efficient synthetic routes, including multi-step syntheses and late-stage diversification strategies.
Utilize parallel or high-throughput approaches to generate focused compound libraries.
Troubleshoot and optimize challenging reactions with scientific rigor and independence.
Scale synthesis of intermediates and final compounds from milligram to decagram quantities.
Collaborate closely with Medicinal Chemistry and cross-functional project teams to advance program goals.
Coordinate with external CRO partners to plan and troubleshoot synthetic activities.
Purify and characterize compounds using NMR, LC-MS, and related analytical techniques.
Maintain high-quality electronic lab documentation suitable for IP and regulatory standards.
Clearly communicate experimental rationale, progress, and results to internal and external stakeholders.
Qualifications
M.S. or Ph.D. in Organic Chemistry or related discipline with 4+ years of pharmaceutical or biotechnology industry experience.
This modern catalysis would be in the specific areas of radical cross couplings (transition metal, photochemical, or electrochemical catalysis).
Key experience with "sp2/sp3" or "sp3/sp3" cross couplings.
Strong foundation in modern synthetic organic chemistry with demonstrated application of enabling technologies (e.g., photocatalysis, electrochemistry, transition metal–mediated transformations).
Experience with parallel synthesis, high-throughput experimentation, or automated reaction platforms.
Proven ability to design and execute robust, scalable multi-step syntheses.
Experience delivering high-quality compounds across varying scales.
Prior experience working effectively with CRO partners.
Excellent documentation practices and strong analytical interpretation skills.
Strong communication skills and collaborative mindset.
#IND-SPG

Estimated Min Rate : $65.00

Estimated Max Rate : $77.00
What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:
Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
Health Savings Account (HSA) (for employees working 20+ hours per week)
Life & Disability Insurance (for employees working 20+ hours per week)
MetLife Voluntary Benefits
Employee Assistance Program (EAP)
401K Retirement Savings Plan
Direct Deposit & weekly epayroll
Referral Bonus Programs
Certification and training opportunities
Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Visit to contact us if you are an individual with a disability and require accommodation in the application process.
For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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High-Throughput Synthetic Chemist Job at Yoh, A Day & Zimmermann Company, South San Francisco, CA

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